منابع مشابه
Oxidative Stress and Raloxifene
We read “Effects of raloxifene on bone metabolism in hemodialysis patients with type 2 diabetes” by Saito et al. (1) with a great interest. This paper shows that raloxifene works in diabetic or non-diabetic hemodialysis patients to reduce bone loss. This was shown by means of significant decrease in NTx and a significant increase in SOS measurements in both treatment groups compared to the un-t...
متن کاملRaloxifene improves endothelial dysfunction in hypertension by reduced oxidative stress and enhanced nitric oxide production.
BACKGROUND It has not been completely clarified whether selective estrogen receptor modulators (SERMs) such as raloxifene exert vasoprotective effects similar to those of estrogens. METHODS AND RESULTS To investigate vascular effects of raloxifene, male spontaneously hypertensive rats were treated for 10 weeks with either raloxifene (10 mg x kg(-1) x d(-1)) or vehicle. Raloxifene improved end...
متن کاملOxidative Stress and Human Disease: a Review
Background: The human body needs both types of oxidants (free radicals) and antioxidants for normal metabolism, signal transduction mechanism, and the order of cellular activity. Free radicals can be either harmful or helpful to the body, in fact, they play a dual role as both toxic and beneficial compounds. The human body has the natural antioxidant defense mechanism to counteract the free rad...
متن کاملoxidative stress and neurodegeneration
neurodegeneration is a complex and multifaceted process leading to many chronic disease states. a conventional definition implies a progressive neuronal death, which usually affects a specific population of nerve cells the vulnerability of which determines the clinical manifestations of a particular neurodegenerative disease. the neurodegenerative process is associated with many events. each ev...
متن کاملoxidative stress and antioxidants
the first reaction between food components and biological tissues occurs in the oral cavity. saliva modulates the ecosystem in the oral cavity and plays a critical role in oral homeostasis. in addition, saliva is a first line of defense against free radical-mediated stress. salivary antioxidant defense mechanisms seem to be very important. in this study we discuss in detail free radicals (fr) a...
متن کاملOxidative Stress and Schizophrenia
Many studies show that oxidative stress is a pathophysiological mechanism of schizophrenia. Elevated oxidative stress levels and the damage to the antioxidant defense system can observed in early schizophrenia. High oxidation levels damage lipids, proteins, nucleic acids and other tissues. Antioxidant defense system imbalance has been observed in both neuroleptic-naïve first-episode schizophren...
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عنوان ژورنال:
international journal of endocrinology and metabolismجلد ۱۰، شماره ۳، صفحات ۵۷۷-۵۷۸
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